![]() Nineteen patients developed a second episode of iron deficiency or depletion concordance of recurrent pica (or absence of pica) was 95%. Mean total iron-binding capacity was higher and mean serum ferritin was lower in patients with pica. Thrombocytosis occurred only in women and was more prevalent in those with pica (20.4% vs. ![]() Mean hemoglobin and mean corpuscular volume (MCV) were lower and mean red blood cell distribution width (RDW) and platelet count were higher in patients with pica. The prevalence of iron deficiency, with or without anemia, did not differ significantly between patients with and without pica reports. In univariable analyses, patients with pica had lower mean age, black race/ethnicity, and higher prevalences of cardiopulmonary and epithelial manifestations. 118 patients (45.0%) reported pica of these, 87.3% reported ice pica (pagophagia). There were 230 women (184 white, 46 black ages 19-91 y) and 32 men (31 white, 1 black ages 24-81 y). We performed univariable comparisons and stepwise forward logistic regression analyses to identify significant correlates of pica. Iron depletion was defined as serum ferritin (SF) <112 pmol/L. Iron deficiency was defined as both SF <45 pmol/L and TS <10%. We excluded patients with serum creatinine >133 μmol/L or disorders that could affect erythrocyte or iron measures. We tabulated their sex, age, race/ethnicity, body mass index, symptoms and causes of iron deficiency or depletion, serum iron and complete blood count measures, and other conditions at diagnosis before intravenous iron dextran was administered. We reviewed charts of 262 non-pregnant adult outpatients (ages ≥18 y) who required treatment with intravenous iron dextran. We sought to identify clinical and laboratory correlates of pica in adults with iron deficiency or depletion using univariable and stepwise forward logistic regression analyses. ![]() There are many descriptions of the association of pica with iron deficiency in adults, but there are few reports in which observations available at diagnosis of iron deficiency were analyzed using multivariable techniques to identify significant predictors of pica.
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